For Research Use Only in the United States. Not for use in diagnostic procedures.

The MicroVue CICP ***** measures type I C-terminal collagen propeptide (CICP) in serum. CICP may be useful as a biochemical indicator of collagen production and growth.

Collagen, the triple-helical molecule which forms the fibrous framework of all connective tissues, is synthesized as procollagen, a larger precursor molecule. Procollagen consists of mature collagen with extension peptides at both the amino and carboxy termini. These extension peptides, or propeptides, are cleaved from the collagen molecule by specific proteases prior to incorporation of collagen into a growing collagen fibril. The release of these peptides into the circulation provides a stoichiometric representation of the production of collagen.